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“We are always excited to recognize the dedication, excellence, inspirational outlook and commitment of our honorees, and this year is no exception.These recipients serve as role models to their peers and represent some of the best of the best of the athletic training profession,” said NATA Honors and Awards Committee Chair Charlie Thompson, MS, ATC.Part of the reason for the impulsive willingness to adopt protective group chemistry is most surely connected to the fact that only minor quantities of end material are required for many applications, particularly within the academic sector.Purification by flash column chromatography then easily becomes a practical, standardized procedure.
In principle, they can function as inexpensive, chiral and densely functionalized starting materials.
On the other hand, the use of amino acid starting materials routinely necessitates protective group chemistry, and in reality, large-scale preparations of even the simplest side-chain derivatives of many amino acids often become annoyingly strenuous due to the necessity of employing protecting groups, on one or more of the amino acid functionalities, during the synthetic sequence.
However, in the case of hydroxyamino acids such as hydroxyproline, serine, threonine, tyrosine and 3,4-dihydroxyphenylalanine (DOPA), many O-acyl side-chain derivatives are directly accessible via a particularly expedient and scalable method not commonly applied until recently.
In the case of hydroxy-α-amino acids, any side-chain acylation will, often for no better reason than intuitive inclination or accustomed habit, commonly direct an organic chemist to adopt the ubiquitous Schotten–Baumann-type alkaline acylation conditions (albeit not necessarily the aqueous conditions used in the original procedure) , both for attachment of prerequisite protective groups at the amino and carboxy termini of the amino acid (resulting in carbamate and/or ester protective groups) , as well as for the subsequent side-chain acylation.
Relevant examples are too numerous to render possible any exhaustive or useful listing herein, but use of modern computerized structure-adapted database searches will uncover such protected amino acid derivatives in abundance, with little effort involved.